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World J Gastroenterol. 2011 Nov 28;17(44):4922-7. doi: 10.3748/wjg.v17.i44.4922.

SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells.

Author information

  • 1The Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun 130024, Jilin Province, China.

Abstract

AIM:

To confirm the role of sex-determining region Y-box 7 (Sox7) in aspirin-mediated growth inhibition of COX-independent human colorectal cancer cells.

METHODS:

The cell survival percentage was examined by MTT (Moto-nuclear cell direc cytotoxicity) assay. SOX7 expression was assessed by using reverse transcription-polymerase chain reaction and Western blotting. SB203580 was used to inhibit the p38MAPK signal pathway. SOX7 promoter activity was detected by Luciferase reporter assay.

RESULTS:

SOX7 was upregulated by aspirin and was involved in aspirin-mediated growth inhibition of SW480 human colorectal cancer cells. The p38MAPK pathway played a role in aspirin-induced SOX7 expression, during which the AP1 transcription factors c-Jun and c-Fos upregulated SOX7 promoter activities.

RESULTS:

SOX7 is upregulated by aspirin and is involved in aspirin-mediated growth inhibition of human colorectal cancer SW480 cells.

KEYWORDS:

Aspirin; Colorectal cancer; SB203580; SOX7; p38MAPK

PMID:
22171135
PMCID:
PMC3235637
DOI:
10.3748/wjg.v17.i44.4922
[PubMed - indexed for MEDLINE]
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