Background: Eosinophilic oesophagitis is a chronic inflammatory condition in the oesophagus. There has been increasing awareness of this disease in recent years as a common cause of dysfunction of the oesophagus in children and adults.
Material and method: The review is based on a search in PubMed, scrutiny of reference lists and the authors' experience of adults and children with eosinophilic oesophagitis.
Results: Eosinophilic oesophagitis is being diagnosed increasingly often in western countries. Men are affected three times as often as women. The disease may start at any age, but does so most frequently in children and young adults. Dysphagia and impaction of food in the oesophagus are the most common symptoms in adolescents and adults. In children the commonest symptoms are eating problems, abdominal pain, nausea and retarded growth. In many patients the mechanism behind the condition is probably an allergic reaction in the oesophagus to food, and over half the patients have an atopic disposition. The diagnosis is based on clinical findings, typical findings on endoscopy and eosinophilic granulocytes in the oesophageal mucosa. Treatment possibilities include restriction of diet, locally acting corticosteroids and endoscopic dilatation.
Interpretation: Eosinophilic oesophagitis is being diagnosed in an increasing number of patients, but it is not certain whether this is due to increased occurrence or increased awareness by doctors. Knowledge of the disease is important because simple endoscopic or medical treatment leads to a good result in most patients, and can prevent complications such as stricture formation and food impaction in the oesophagus.