Send to

Choose Destination
See comment in PubMed Commons below
Cold Spring Harb Symp Quant Biol. 2011;76:145-54. doi: 10.1101/sqb.2011.76.010686. Epub 2011 Dec 14.

A new approach to an old problem: synthetic biology tools for human disease and metabolism.

Author information

Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.


The field of synthetic biology seeks to develop engineering principles for biological systems. Along these lines, synthetic biology can address human metabolic disease through the development of genetic approaches to the study and modification of metabolism. The re-engineering of natural metabolic states provides fundamental understanding of the integrated components underlying dysfunctional metabolism. Alternatively, the development of biological devices that can both sense and affect metabolic states could render unique control over disease states. In this chapter, we discuss the advancement of synthetic biological approaches to monitoring and engineering metabolism, as well as prospects for synthetic biology's future role in the prevention and treatment of metabolic disease.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center