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J Enzyme Inhib Med Chem. 2012 Dec;27(6):886-91. doi: 10.3109/14756366.2011.638921. Epub 2011 Dec 14.

Carbonic anhydrases inhibitory effects of new benzenesulfonamides synthesized by using superacid chemistry.

Author information

1
Laboratoire Synthèse et Réactivité des Substances Naturelles, Poitiers Cedex, France.

Abstract

A series of benzofused sultams and fluorinated benzenesulfonamides were synthesized in superacid HF/SbF(5) from simple N-allylic derivatives. Almost all of these original compounds showed micromolar inhibitory activities against carbonic anhydrases I and II. The fluorinated derivatives inhibit better the tumor-associated isoforms IX and XII, and one of the tested compounds showed inhibition in the nanomolar range.

PMID:
22168802
DOI:
10.3109/14756366.2011.638921
[Indexed for MEDLINE]

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