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Future Med Chem. 2012 Jan;4(1):73-86. doi: 10.4155/fmc.11.165.

Recent advances in the application of antibodies as therapeutics.

Author information

1
Molecular Therapeutics, School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.

Abstract

The application of antibodies as therapeutic agents in the treatment of cancer now represents a significant proportion of the oncology drug arena. Despite this success, the ability to engineer and exploit antibodies in many different formats is ensuring that new avenues for their therapeutic application are constantly being examined. This review examines a selection of novel antibody-based therapeutic strategies that are currently in late preclinical and clinical evaluation.

PMID:
22168165
DOI:
10.4155/fmc.11.165
[Indexed for MEDLINE]

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