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Ann Behav Med. 2012 Jun;43(3):402-8. doi: 10.1007/s12160-011-9333-6.

History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer.

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1
Moffitt Cancer Center, Tampa, 33612 FL, USA. heather.jim@moffitt.org

Abstract

BACKGROUND:

Data are scarce about whether past history of major depressive disorder in the absence of current depression places breast cancer patients at risk for worse quality of life.

PURPOSE:

The current study prospectively examined quality of life during chemotherapy in breast cancer patients with a history of resolved major depressive disorder (n = 29) and no history of depression (n = 144).

METHODS:

Women with Stages 0-II breast cancer were assessed prior to and at the completion of chemotherapy. Major depressive disorder was assessed via structured interview and quality of life with the SF-36.

RESULTS:

Patients with past major depressive disorder displayed greater declines in physical functioning relative to patients with no history of depression (p ≤ 0.01).

CONCLUSIONS:

Findings suggest that breast cancer patients with a history of resolved major depressive disorder are at increased risk for declines in physical functioning during chemotherapy relative to patients with no history of depression.

PMID:
22167580
PMCID:
PMC3424106
DOI:
10.1007/s12160-011-9333-6
[Indexed for MEDLINE]
Free PMC Article
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