Format

Send to

Choose Destination
Viruses. 2011 Nov;3(11):2192-213. doi: 10.3390/v3112192. Epub 2011 Nov 9.

The molecular biology of feline immunodeficiency virus (FIV).

Author information

1
Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK. jck33@mole.bio.cam.ac.uk

Abstract

Feline immunodeficiency virus (FIV) is widespread in feline populations and causes an AIDS-like illness in domestic cats. It is highly prevalent in several endangered feline species. In domestic cats FIV infection is a valuable small animal model for HIV infection. In recent years there has been sa significant increase in interest in FIV, in part to exploit this, but also because of the potential it has as a human gene therapy vector. Though much less studied than HIV there are many parallels in the replication of the two viruses, but also important differences and, despite their likely common origin, the viruses have in some cases used alternative strategies to overcome similar problems. Recent advances in understanding the structure and function of FIV RNA and proteins and their interactions has enhanced our knowledge of FIV replication significantly, however, there are still many gaps. This review summarizes our current knowledge of FIV molecular biology and its similarities with, and differences from, other lentiviruses.

KEYWORDS:

FIV; retrovirus, lentivirus

PMID:
22163340
PMCID:
PMC3230847
DOI:
10.3390/v3112192
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center