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Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):103-12. doi: 10.1159/000327518. Epub 2011 Apr 27.

Midlife healthy-diet index and late-life dementia and Alzheimer's disease.

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Department of Neurology, University of Eastern Finland, Kuopio, Kuopio, Finland.



To study long-term effects of dietary patterns on dementia and Alzheimer's disease (AD).


Of 525 subjects randomly selected from population-based cohorts surveyed at midlife, a total of 385 (73%) subjects were re-examined 14 years later in the CAIDE study. A healthy-diet index (range 0-17) was constructed including both healthy and unhealthy dietary components.


Persons with a healthy diet (healthy-diet index >8 points) had a decreased risk of dementia (OR 0.12, 95% CI 0.02-0.85) and AD (OR 0.08, 95% CI 0.01-0.89) compared with persons with an unhealthy diet (0-8 points), adjusting for several possible confounders.


Healthy diet at midlife is associated with a decreased risk of dementia/AD in late life. These findings highlight the importance of dietary patterns and may make more effective measures for dementia/AD prevention or postponement possible.


Alzheimer's disease; Cohort studies; Dementia; Diet; Population-based studies; Risk factors

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