Format

Send to

Choose Destination
See comment in PubMed Commons below
Dement Geriatr Cogn Dis Extra. 2011 Jan;1(1):51-61. doi: 10.1159/000323864. Epub 2011 Jan 22.

Impairment in proverb interpretation as an executive function deficit in patients with amnestic mild cognitive impairment and early Alzheimer's disease.

Author information

  • 1Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Abstract

BACKGROUND/AIMS:

Proverb interpretation is assumed to reflect executive functions. We hypothesized that proverb interpretation is impaired in patients with amnestic mild cognitive impairment (aMCI) diagnosed as single-domain impairment by common neuropsychological testing.

METHODS:

We compared performance in a proverb interpretation test in single-domain aMCI patients and patients with early Alzheimer's disease (EAD).

RESULTS:

The groups with aMCI and EAD performed significantly worse than healthy controls. Both patient groups gave concrete answers with a similar frequency. However, patients with EAD tended to give senseless answers more frequently.

CONCLUSIONS:

Our data suggest that in patients diagnosed as single-domain aMCI, deterioration of executive functions is detectable with subtle and appropriate neuropsychological testing. Implementation of these procedures may improve the early prediction of AD.

KEYWORDS:

Amnestic mild cognitive impairment; Concrete thinking; Early Alzheimer's disease; Executive dysfunction; Neuropsychological testing; Non-literal language

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland Icon for PubMed Central
    Loading ...
    Write to the Help Desk