Strong correlation between liver and serum levels of hepatitis C virus core antigen and RNA in chronically infected patients

V Descamps; A Op de Beeck; C Plassart; E Brochot; C François; F Helle; M Adler; N Bourgeois; D Degré; G Duverlie; S Castelain

doi:10.1128/JCM.06503-11

Strong correlation between liver and serum levels of hepatitis C virus core antigen and RNA in chronically infected patients

J Clin Microbiol. 2012 Feb;50(2):465-8. doi: 10.1128/JCM.06503-11. Epub 2011 Dec 7.

Authors

V Descamps¹, A Op de Beeck, C Plassart, E Brochot, C François, F Helle, M Adler, N Bourgeois, D Degré, G Duverlie, S Castelain

Affiliation

¹ Virology Department, Amiens University Hospital, South Hospital, Amiens, France.

Abstract

HCV core antigen (Ag) and HCV RNA levels were evaluated in matched liver biopsy samples and sera from 22 patients with hepatitis C infection by using the quantitative Architect HCV Ag immunoassay and a real-time RT-qPCR assay, respectively. The data showed a strong correlation between liver and serum compartments of HCV Ag levels (r = 0.80) and HCV RNA levels (r = 0.87). In summary, the serum HCV Ag and RNA levels reflect the intrahepatic values.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Biopsy
Female
Hepacivirus / isolation & purification*
Hepatitis C, Chronic / virology*
Humans
Immunoassay
Liver / virology*
Male
Middle Aged
RNA, Viral / analysis*
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Serum / virology*
Statistics as Topic
Viral Core Proteins / analysis*

Substances

RNA, Viral
Viral Core Proteins
nucleocapsid protein, Hepatitis C virus