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Ann Neurol. 2011 Nov;70(5):857-61. doi: 10.1002/ana.22608.

Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data.

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1
Department of Radiology, Washington University School of Medicine, St Louis, MO 63108, USA.

Abstract

Amyloid-beta (Aβ) accumulation was evaluated with 2 [(11)C]Pittsburgh compound B (PiB) positron emission tomography scans about 2.5 years apart in 146 cognitively normal adults. Seventeen of 21 participants with initially elevated Aβ deposition demonstrated subsequent Aβ plaque growth (approximately 8.0% per year), and none reverted to a state of no Aβ deposits. Ten individuals converted from negative to positive PiB status, based on a threshold of the mean cortical binding potential, representing a conversion rate of 3.1% per year. Individuals with an ε4 allele of apolipoprotein E demonstrated increased incidence of conversion (7.0% per year). Our findings suggest that the major growth in Aβ burden occurs during a preclinical stage of Alzheimer disease (AD), prior to the onset of AD-related symptoms.

PMID:
22162065
PMCID:
PMC3243969
DOI:
10.1002/ana.22608
[Indexed for MEDLINE]
Free PMC Article
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