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Curr Protoc Bioinformatics. 2011 Dec;Chapter 11:Unit 11.1.. doi: 10.1002/0471250953.bi1101s36.

An introduction to the informatics of "next-generation" sequencing.

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1
Ontario Institute for Cancer Research, Toronto, Ontario, Canada.

Abstract

Next-generation sequencing (NGS) packs the sequencing throughput of a 2000's-era genome center into a single affordable machine. However, software developed for conventional sequencing technologies is often inadequate to deal with the nature of NGS technologies, which produce short, massively parallel reads. This unit surveys the software packages that are available for managing and analyzing NGS data.

PMID:
22161566
DOI:
10.1002/0471250953.bi1101s36
[Indexed for MEDLINE]
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