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Adv Exp Med Biol. 2012;736:325-35. doi: 10.1007/978-1-4419-7210-1_19.

A systems-biology approach to yeast actin cables.

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1
Department of Physics, Lehigh University, Bethlehem, PA 18015, USA. tyler.gates.drake@gmail.com

Abstract

We focus on actin cables in yeast as a model system for understanding cytoskeletal organization and the workings of actin itself. In particular, we highlight quantitative approaches on the kinetics of actin-cable assembly and methods of measuring their morphology by image analysis. Actin cables described by these studies can span greater lengths than a thousand end-to-end actin-monomers. Because of this difference in length scales, control of the actin-cable system constitutes a junction between short-range interactions - among actin-monomers and nucleating, polymerization-facilitating, side-binding, severing, and cross-linking proteins - and the emergence of cell-scale physical form as embodied by the actin cables themselves.

PMID:
22161338
PMCID:
PMC3241217
DOI:
10.1007/978-1-4419-7210-1_19
[Indexed for MEDLINE]
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