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J Med Toxicol. 2012 Mar;8(1):43-51. doi: 10.1007/s13181-011-0198-7.

Prediction of drug response and safety in clinical practice.

Author information

1
Rocky Mountain Poison and Drug Center, Denver, CO, USA. andrew.monte@ucdenver.edu

Abstract

Many clinicians hoped that the completion of the Human Genome Project would result in "individualized drug therapy," i.e., determining the right medication at the right dose 100% of the time based upon the individual's genetics. The pharmacogenomic prediction of drug efficacy and safety has not become a reality due to continuing realization of the complexity dictating the human-drug interaction. New methods of metabolomics, proteomics, and transcriptomics that account for this complexity hold promise for translational researchers hoping to increase drug efficacy and decrease drug toxicity.

PMID:
22160757
PMCID:
PMC3550218
DOI:
10.1007/s13181-011-0198-7
[Indexed for MEDLINE]
Free PMC Article
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