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Acta Cir Bras. 2012 Jan;27(1):71-5.

Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats.

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1
Laboratory of Morphology and Structural Biology, Research and Technology Institute, Tiradentes University, Sergipe, Brazil. sonia.sol@ibest.com.br

Abstract

PURPOSE:

To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats.

METHODS:

Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique.

RESULTS:

The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003).

CONCLUSION:

These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.

PMID:
22159442
[Indexed for MEDLINE]
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