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Chem Commun (Camb). 2012 Mar 14;48(22):2746-8. doi: 10.1039/c2cc16654b. Epub 2011 Dec 7.

Light-activatable molecular beacons with a caged loop sequence.

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1
Goethe University Frankfurt, Frankfurt Institute for Molecular Life Sciences (FMLS), Max-von-Laue-Str. 15, 60438 Frankfurt (M), Germany.

Abstract

We have synthesized molecular beacons with caged nucleobases in the loop region. These constructs remain non-fluorescent in the presence of their target RNA but can be fully activated by light (366 or 405 nm) in vitro and in HEK293 cells. We suggest that this technology will be useful for single molecule RNA tracking in living cells.

PMID:
22159276
DOI:
10.1039/c2cc16654b
[Indexed for MEDLINE]
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