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Exerc Sport Sci Rev. 2012 Apr;40(2):73-8. doi: 10.1097/JES.0b013e31824580c6.

What is the role of titin in active muscle?

Author information

1
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011-5640, USA. Jenna.Monroy@nau.edu

Abstract

Several properties of muscle defy explanation solely based on the sliding filament-swinging cross-bridge theory. Indeed, muscle behaves as though there is a dynamic "spring" within the sarcomeres. We propose a new "winding filament" mechanism for how titin acts, in conjunction with the cross-bridges, as a force-dependent spring. The addition of titin into active sarcomeres resolves many puzzling muscle characteristics.

PMID:
22157359
DOI:
10.1097/JES.0b013e31824580c6
[Indexed for MEDLINE]

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