Format

Send to

Choose Destination
Gut Microbes. 2012 Mar-Apr;3(2):88-92. doi: 10.4161/gmic.18602. Epub 2012 Mar 1.

Typhoid fever: "you can't hit what you can't see".

Author information

1
Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, CA USA.

Abstract

The host restricts dissemination of invasive enteric pathogens, such as non-typhoidal Salmonella serovars, by mounting acute inflammatory responses characterized by the recruitment of neutrophils. However, some enteric pathogens, such as Salmonella enterica serovar Typhi (S. typhi), can bypass these defenses and cause an invasive bloodstream infection known as typhoid fever. Recent studies on virulence mechanisms of S. typhi suggest that tight regulation of virulence gene expression during the transition from the intestinal lumen into the intestinal mucosa enables this pathogen to evade detection by the innate immune system, thereby penetrating defenses that prevent bacterial dissemination. This example illustrates how the outcome of host pathogen interaction at the intestinal mucosal interface can alter the clinical presentation and dictate the disease outcome.

PMID:
22156762
PMCID:
PMC3370952
DOI:
10.4161/gmic.18602
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center