Format

Send to

Choose Destination
See comment in PubMed Commons below
Acta Cytol. 2011;55(6):539-43. doi: 10.1159/000333230. Epub 2011 Dec 9.

Repeatedly nondiagnostic thyroid fine-needle aspirations do not modify malignancy risk.

Author information

1
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., USA.

Abstract

OBJECTIVE:

Thyroid nodules with nondiagnostic (ND) fine-needle aspirations (FNA) typically undergo repeat sampling. While repeat FNA is often diagnostic, little is known regarding the significance of repeatedly ND aspirates. Limited data suggest there is very low, if any, risk of malignancy for repeatedly ND FNAs.

STUDY DESIGN:

We performed a retrospective analysis of ND thyroid FNAs over a nearly 6-year period at our institution to further address this question.

RESULTS:

There were 834 ND thyroid FNAs, representing 694 distinct thyroid nodules. Repeat FNA was performed after an initial ND aspirate in 52% of cases (363/694); 19% (70/363) had at least one additional ND diagnosis on repeat FNA. Surgical follow-up was available for 57 cases. Malignancy was identified histologically in 21% (9/42) of nodules after a single ND FNA and in 20% (3/15) of nodules with 2 or more repeatedly ND aspirates. Accounting for all benign cytologic follow-up, the overall risk of malignancy was 4% [12/303; 3.5% (9/255) following a single ND FNA and 6.3% (3/48) after repeated ND FNAs].

CONCLUSION:

We observed no modification of malignancy risk when repeated FNAs were ND. Clinical management for an ND aspirate should remain repeat aspiration along with clinical and sonographic correlation.

PMID:
22156463
DOI:
10.1159/000333230
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for S. Karger AG, Basel, Switzerland
    Loading ...
    Support Center