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Gene. 2012 Feb 15;494(1):130-9. doi: 10.1016/j.gene.2011.11.031. Epub 2011 Nov 25.

Bio-informatics based analysis of genes implicated in alcohol mediated liver injury.

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1
Life Science Division, AU-KBC Research Centre, MIT Campus of Anna University, Chromepet, Chennai, India.

Abstract

Alcohol induced liver injury has been studied extensively. Using literature search and bioinformatics tools, the present study characterizes the genes involved in alcohol induced liver injury. The cellular and metabolic processes in which genes involved in alcohol induced liver injury are implicated are also discussed. The genes related to alcohol induced liver injury are also involved in affecting certain molecular functions and metabolism of drugs, besides being associated with diseases. In conclusion, the changes in regulation of genes implicated in alcohol induced liver injury apart from causing alcohol mediated hepatic dysfunction may affect other vital processes in the body.

PMID:
22155707
DOI:
10.1016/j.gene.2011.11.031
[Indexed for MEDLINE]
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