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Biochim Biophys Acta. 2012 Mar;1819(3-4):313-21. doi: 10.1016/j.bbagrm.2011.11.002. Epub 2011 Dec 9.

Centromeric chromatin and the pathway that drives its propagation.


The centromere is the locus that directs chromosomal inheritance at cell division. While centromeres in diverse eukaryotes are commonly found at sites of repetitive DNA, their location is epigenetically specified. The histone H3 variant CENP-A is the prime candidate for epigenetically marking the centromere, and recent work has uncovered several additional proteins that play key roles in centromere assembly and maintenance. We describe advances in the identification and characterization of proteins that form the centromere, and focus on recent findings that have advanced our understanding of the assembly of functional centromeric chromatin. This article is part of a Special Issue entitled: Histone chaperones and chromatin assembly.

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