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J Neuroimmunol. 2012 Jan 18;242(1-2):52-9. doi: 10.1016/j.jneuroim.2011.11.005. Epub 2011 Dec 6.

Immune profiling of Alzheimer patients.

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  • 1Department of Internal Medicine II, Center for Medical Research, University of Tübingen, Tübingen Aging and Tumor Immunology group, Waldhörnlestr. 22, 72072 Tübingen, Germany.


Alzheimer's disease (AD) is characterized by extracellular senile plaques in the brain, containing amyloid-β peptide (Aβ). We identify immunological differences between AD patients and age-matched controls greater than those related to age itself. The biggest differences were in the CD4+ rather than the CD8+ T cell compartment resulting in lower proportions of naïve cells, more late-differentiated cells and higher percentages of activated CD4+CD25+ T cells without a Treg phenotype in AD patients. Changes to CD4+ cells might be the result of chronic stimulation by Aβ present in the blood. These findings have implications for diagnosis and understanding the aetiology of the disease.

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