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Eur Neuropsychopharmacol. 2012 Jun;22(6):415-8. doi: 10.1016/j.euroneuro.2011.10.002. Epub 2011 Dec 7.

Pilot randomized, controlled trial of pramipexole to augment antipsychotic treatment.

Author information

1
Department of Psychiatry, St. Vincent's Hospital Westchester, Harrison, NY 10528, USA. jkelleher@svwsjmc.org

Abstract

The preferential dopamine D(3)-agonist pramipexole (4.25±0.38 mg/day) or placebo were added for up to 12 weeks to ongoing antipsychotic treatment for 24 adult patients with DSM-IV schizophrenia or schizoaffective disorder. Pramipexole was generally well-tolerated (82% trial-completion), and yielded greater decreases in PANSS-total scores (drug/placebo=2.1; p=0.04), with similar decreases in PANSS positive and negative scores and 6.7-fold greater reduction of serum prolactin concentrations compared to placebo. There were no differences in ratings of mood, cognition or extrapyramidal symptoms, all of which were low at intake.

PMID:
22153972
DOI:
10.1016/j.euroneuro.2011.10.002
[Indexed for MEDLINE]
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