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Curr Opin Cell Biol. 2012 Feb;24(1):141-7. doi: 10.1016/j.ceb.2011.11.002. Epub 2011 Dec 5.

Putting structure into context: fitting of atomic models into electron microscopic and electron tomographic reconstructions.

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1
Sanford-Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA. niels@sanfordburnham.org

Abstract

A complete understanding of complex dynamic cellular processes such as cell migration or cell adhesion requires the integration of atomic level structural information into the larger cellular context. While direct atomic-level information at the cellular level remains inaccessible, electron microscopy, electron tomography and their associated computational image processing approaches have now matured to a point where sub-cellular structures can be imaged in three dimensions at the nanometer scale. Atomic-resolution information obtained by other means can be combined with this data to obtain three-dimensional models of large macromolecular assemblies in their cellular context. This article summarizes some recent advances in this field.

PMID:
22152946
PMCID:
PMC3294126
DOI:
10.1016/j.ceb.2011.11.002
[Indexed for MEDLINE]
Free PMC Article
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