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Clin Exp Hypertens. 2012;34(1):8-16. doi: 10.3109/10641963.2011.628727. Epub 2011 Dec 9.

The usefulness of γ-glutamyltransferase as a marker of cardiovascular function in Africans and Caucasians: the SABPA study.

Author information

1
Hypertension in Africa Research Team, School for Physiology, North-West University, Potchefstroom Campus, Potchefstroom, South Africa. Hugo.Huisman@nwu.ac.za

Abstract

AIM:

Serum γ-glutamyltransferase (GGT) is increasingly regarded as a marker of vascular function. However, the usefulness of this marker is in dispute. Gender and ethnic differences, as well as the serum level range where correlations with vascular function will emerge, may complicate the usefulness of GGT. The aim is to compare correlations with markers of vascular function between African and Caucasian groups.

METHODS:

This cross-sectional target population study involved four groups of African and Caucasian men and women of 100 participants each. Fasting lipids, GGT, C-reactive protein (CRP), reactive oxygen species, and glycosylated hemoglobin (HbA1c) were determined as well as blood pressure, carotid intima-media thickness (CIMT), and left ventricular hypertrophy.

RESULTS:

γ-Glutamyltransferase levels were significantly higher in Africans compared with Caucasians and also higher in men than in women. γ-Glutamyltransferase correlated with triglycerides in all four groups and after adjusting the correlations sustained in the male groups but disappeared in women. Correlations existed between GGT and blood pressure, except for the African women. After adjustments, CIMT correlated with GGT in Caucasian men (r = 0.29; P < .01). Glycosylated hemoglobin was associated with GGT in Caucasian women (r = 0.26; P = .01) as well as CRP (r = 0.36; P < .01). When the groups were divided into low and high GGT groups by median split, most of the correlations disappeared in the high GGT groups.

CONCLUSIONS:

Gender and ethnic-specific associations occurred regarding GGT and variables associated with cardiovascular function. With high levels of GGT the correlations diminished. The usefulness of GGT as a marker of vascular dysfunction seems limited.

PMID:
22148881
DOI:
10.3109/10641963.2011.628727
[Indexed for MEDLINE]

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