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Nat Rev Mol Cell Biol. 2011 Dec 7;13(1):13-26. doi: 10.1038/nrm3248.

Walking to work: roles for class V myosins as cargo transporters.

Author information

1
Laboratory of Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. hammerj@nhlbi.nih.gov

Abstract

Cells use molecular motors, such as myosins, to move, position and segregate their organelles. Class V myosins possess biochemical and structural properties that should make them ideal actin-based cargo transporters. Indeed, studies show that class V myosins function as cargo transporters in yeast, moving a range of organelles, such as the vacuole, peroxisomes and secretory vesicles. There is also increasing evidence in vertebrate cells that class V myosins not only tether organelles to actin but also can serve as short-range, point-to-point organelle transporters, usually following long-range, microtubule-dependent organelle transport.

PMID:
22146746
DOI:
10.1038/nrm3248
[Indexed for MEDLINE]

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