Format

Send to

Choose Destination
Crit Care. 2011;15(6):236. doi: 10.1186/cc10359. Epub 2011 Dec 5.

Year in review 2010: Critical Care--Multiple organ dysfunction and sepsis.

Author information

1
Service de Réanimation Polyvalente, Hôpital Raymond Poincaré (AP-HP), Université de Versailles Saint Quentin, 104, bd, Raymond Poincaré, 92380 Garches, France.

Abstract

This review summarizes new insights in the pathophysiologic implications of inflammation and microvascular alterations in organ dysfunction, as well as genetic factor contribution, from clinical and experimental studies that were published in 2010 in Critical Care in the fields of multiple organ dysfunction and sepsis. New diagnostic and prognostic markers of organ dysfunction are presented. Evaluations of novel therapeutic strategies, including implementation of international guidelines, modulation of inflammation and coagulation, and prevention of ventilator-induced lung injury and acute kidney injury, are reported. The results of these experimental studies and clinical trials are discussed in the context of the current relevant scientific and clinical background.

PMID:
22146601
PMCID:
PMC3388699
DOI:
10.1186/cc10359
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center