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Nucleic Acids Res. 2012 Jan;40(Database issue):D252-60. doi: 10.1093/nar/gkr1189. Epub 2011 Dec 6.

Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequences.

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1
Department of Computer Science and Engineering, University of Connecticut, Storrs, CT 06269-2155, USA.

Abstract

Minimotif Miner (MnM available at http://minimotifminer.org or http://mnm.engr.uconn.edu) is an online database for identifying new minimotifs in protein queries. Minimotifs are short contiguous peptide sequences that have a known function in at least one protein. Here we report the third release of the MnM database which has now grown 60-fold to approximately 300,000 minimotifs. Since short minimotifs are by their nature not very complex we also summarize a new set of false-positive filters and linear regression scoring that vastly enhance minimotif prediction accuracy on a test data set. This online database can be used to predict new functions in proteins and causes of disease.

PMID:
22146221
PMCID:
PMC3245078
DOI:
10.1093/nar/gkr1189
[Indexed for MEDLINE]
Free PMC Article
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