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Zh Vyssh Nerv Deiat Im I P Pavlova. 2011 Sep-Oct;61(5):615-23.

[Effects of blockade of dopaminergic D1/D2 receptors on behavior of impulsive and self-controlled rats].

[Article in Russian]

Abstract

Selective antagonists of D1 and D2 receptors (SCH 23 390 and raclopride respectively) were injected to rats divided on the basis of preliminary experiments into groups of"self-controlled" (preference of valuable but delayed reinforcement) and "impulsive" (choice of less valuable but immediate reinforcement) animals. Number of omissions of reactions and their latencies were recorded. In "self-controlled" rats, both drugs increased the number of reactions for less valuable immediate reinforcement, i.e., increased impulsiveness, whereas practically did not change the behavior of "impulsive" animals. Introduction of SCH 23 390 to animals ofboth groups increased the number of reaction omissions the effect being stronger in "self-controlled" animals. Raclopride also increased the number of reaction omissions in "self-controlled" rats but only on the next day after the injection. In "impulsive" animals, both drugs increased the latencies of reactions.

PMID:
22145337
[Indexed for MEDLINE]

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