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Science. 2011 Dec 2;334(6060):1293-7. doi: 10.1126/science.1211250.

The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy.

Author information

1
London Research Institute, Cancer Research UK, London WC2A 3LY, UK.

Abstract

Epithelial cells respond to physicochemical damage with up-regulation of major histocompatibility complex-like ligands that can activate the cytolytic potential of neighboring intraepithelial T cells by binding the activating receptor, NKG2D. The systemic implications of this lymphoid stress-surveillance response, however, are unknown. We found that antigens encountered at the same time as cutaneous epithelial stress induced strong primary and secondary systemic, T helper 2 (T(H)2)-associated atopic responses in mice. These responses required NKG2D-dependent communication between dysregulated epithelial cells and tissue-associated lymphoid cells. These data are germane to uncertainty over the afferent induction of T(H)2 responses and provide a molecular framework for considering atopy as an important component of the response to tissue damage and carcinogenesis.

PMID:
22144628
PMCID:
PMC3842529
DOI:
10.1126/science.1211250
[Indexed for MEDLINE]
Free PMC Article

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