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Methods Mol Biol. 2012;814:467-81. doi: 10.1007/978-1-61779-452-0_31.

Pericyte coculture models to study astrocyte, pericyte, and endothelial cell interactions.

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  • 1Department of Neurology, Division of Neuroimmunology, Wayne State University School of Medicine, Detroit, MI, USA.

Abstract

The microvascular pericyte is an integral component of the blood-brain barrier and the neurovascular unit. Most model systems that have been developed to study the functional parameters of these systems have not incorporated the pericyte. In this chapter, we consider pericyte coculture and triple culture systems and detail the methodology, suggestions, and problems with isolation of these unique cells. We also present data to show that triple cultures are ideal to study the role of the CNS pericyte in CNS angiogenesis.

PMID:
22144326
DOI:
10.1007/978-1-61779-452-0_31
[PubMed - indexed for MEDLINE]
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