Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20832-7. doi: 10.1073/pnas.1112708109. Epub 2011 Dec 5.

Phytophthora infestans effector AVRblb2 prevents secretion of a plant immune protease at the haustorial interface.

Author information

1
The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, United Kingdom.

Abstract

In response to pathogen attack, plant cells secrete antimicrobial molecules at the site of infection. However, how plant pathogens interfere with defense-related focal secretion remains poorly known. Here we show that the host-translocated RXLR-type effector protein AVRblb2 of the Irish potato famine pathogen Phytophthora infestans focally accumulates around haustoria, specialized infection structures that form inside plant cells, and promotes virulence by interfering with the execution of host defenses. AVRblb2 significantly enhances susceptibility of host plants to P. infestans by targeting the host papain-like cysteine protease C14 and specifically preventing its secretion into the apoplast. Plants altered in C14 expression were significantly affected in susceptibility to P. infestans in a manner consistent with a positive role of C14 in plant immunity. Our findings point to a unique counterdefense strategy that plant pathogens use to neutralize secreted host defense proteases. Effectors, such as AVRblb2, can be used as molecular probes to dissect focal immune responses at pathogen penetration sites.

PMID:
22143776
PMCID:
PMC3251060
DOI:
10.1073/pnas.1112708109
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center