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Cell Res. 2012 Jan;22(1):14-22. doi: 10.1038/cr.2011.193. Epub 2011 Dec 6.

Signal control through Raf: in sickness and in health.

Author information

1
Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9041, USA.

Abstract

The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.

PMID:
22143568
PMCID:
PMC3351917
DOI:
10.1038/cr.2011.193
[Indexed for MEDLINE]
Free PMC Article

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