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Curr Opin Virol. 2011 Nov;1(5):339-46. doi: 10.1016/j.coviro.2011.09.005.

Non-template functions of viral RNA in picornavirus replication.

Author information

1
Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, United States.

Abstract

The genomic RNA of poliovirus and closely related picornaviruses perform template and non-template functions during viral RNA replication. The non-template functions are mediated by cis-active RNA sequences that bind viral and cellular proteins to form RNP complexes. The RNP complexes mediate temporally dynamic, long-range interactions in the viral genome and ensure the specificity of replication. The 5' cloverleaf (5' CL)-RNP complex serves as a key cis-active element in all of the non-template functions of viral RNA. The 5'CL-RNP complex is proposed to interact with the cre-RNP complex during VPgpUpU synthesis, the 3'NTR-poly(A) RNP complex during negative-strand initiation and the 30 end negative-strand-RNP complex during positive-strand initiation. Co-ordinating these long-range interactions is important in regulating each step in the replication cycle.

PMID:
22140418
PMCID:
PMC3227123
DOI:
10.1016/j.coviro.2011.09.005
[Indexed for MEDLINE]
Free PMC Article

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