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Nucleic Acids Res. 2012 Jan;40(Database issue):D1093-9. doi: 10.1093/nar/gkr1177. Epub 2011 Dec 1.

MOPED: Model Organism Protein Expression Database.

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1
Bioinformatics and High-throughput Analysis Laboratory, High-throughput Analysis Core, Center for Developmental Therapeutics, Seattle Children's Research Institute, Predicitive Analytics, Seattle Children's Hospital, Seattle, WA 98105, USA. eugene.kolker@seattlechildrens.org

Abstract

Large numbers of mass spectrometry proteomics studies are being conducted to understand all types of biological processes. The size and complexity of proteomics data hinders efforts to easily share, integrate, query and compare the studies. The Model Organism Protein Expression Database (MOPED, htttp://moped.proteinspire.org) is a new and expanding proteomics resource that enables rapid browsing of protein expression information from publicly available studies on humans and model organisms. MOPED is designed to simplify the comparison and sharing of proteomics data for the greater research community. MOPED uniquely provides protein level expression data, meta-analysis capabilities and quantitative data from standardized analysis. Data can be queried for specific proteins, browsed based on organism, tissue, localization and condition and sorted by false discovery rate and expression. MOPED empowers users to visualize their own expression data and compare it with existing studies. Further, MOPED links to various protein and pathway databases, including GeneCards, Entrez, UniProt, KEGG and Reactome. The current version of MOPED contains over 43,000 proteins with at least one spectral match and more than 11 million high certainty spectra.

PMID:
22139914
PMCID:
PMC3245040
DOI:
10.1093/nar/gkr1177
[Indexed for MEDLINE]
Free PMC Article
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