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Int J Oncol. 2012 Apr;40(4):1066-70. doi: 10.3892/ijo.2011.1278. Epub 2011 Dec 1.

Tripchlorolide induces cell death in lung cancer cells by autophagy.

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1
Department of Respiratory Medicine, Union Hospital, Fujian Medical University, Fuzhou, Fujian 350001, PR China.

Abstract

It has been demonstrated that triptolide inhibits the growth of several types of cancer cells in vitro and prevents tumor growth in vivo by inducing apoptosis and autophagy. Here we showed that Tripchlorolide (T4) significantly suppressed the proliferation of A549 cells in a dose- and time-dependent manner. This suppressive effect was diminished when cells were pretreated with 3-Methylamphetamine (3-MA). After the cells were treated with T4, the LC3 II protein expression was significantly increased, and autophagosomes were observed by TEM. However, almost no apoptosis was observed in A549 treated with T4. These results suggest that T4 induces A549 cell death predominantly through the activation of the autophagy pathway instead of the apoptosis pathway.

PMID:
22139090
PMCID:
PMC3584525
DOI:
10.3892/ijo.2011.1278
[Indexed for MEDLINE]
Free PMC Article
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