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Oncogene. 2012 Aug 23;31(34):3827-44. doi: 10.1038/onc.2011.552. Epub 2011 Dec 5.

Targeting the epigenome for treatment of cancer.

Author information

1
Division of Molecular Carcinogenesis, Centre for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Abstract

Cancer genome analyses have revealed that the enzymes involved in epigenetic gene regulation are frequently deregulated in cancer. Here we describe the enzymes that control the epigenetic state of the cell, how they are affected in cancer and how this knowledge can be exploited to treat cancer with a new arsenal of selective therapies.

PMID:
22139071
DOI:
10.1038/onc.2011.552
[Indexed for MEDLINE]

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