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Nat Neurosci. 2011 Dec 4;15(1):20-2. doi: 10.1038/nn.3002.

How the 'slow' Ca(2+) buffer parvalbumin affects transmitter release in nanodomain-coupling regimes.

Author information

1
Physiological Institute I, University of Freiburg, Freiburg, Germany.

Abstract

Parvalbumin is thought to act in a manner similar to EGTA, but how a slow Ca(2+) buffer affects nanodomain-coupling regimes at GABAergic synapses is unclear. Direct measurements of parvalbumin concentration and paired recordings in rodent hippocampus and cerebellum revealed that parvalbumin affects synaptic dynamics only when expressed at high levels. Modeling suggests that, in high concentrations, parvalbumin may exert BAPTA-like effects, modulating nanodomain coupling via competition with local saturation of endogenous fixed buffers.

PMID:
22138646
PMCID:
PMC3631701
DOI:
10.1038/nn.3002
[Indexed for MEDLINE]
Free PMC Article

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