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Int J Tuberc Lung Dis. 2012 Feb;16(2):203-5. doi: 10.5588/ijtld.11.0445.

Global isoniazid resistance patterns in rifampin-resistant and rifampin-susceptible tuberculosis.

Author information

1
Division of Tuberculosis Elimination, International Research and Programs Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

Abstract

Following the World Health Organization's endorsement of the Xpert® MTB/RIF assay, which rapidly and simultaneously diagnoses tuberculosis (TB) and detects resistance to rifampin (RMP), the question arises to what extent RMP resistance is an adequate marker for multidrug-resistant TB (MDR-TB). A retrospective analysis of data from >81 countries and subnational settings demonstrated that >40% of RMP-resistant isolates from new TB cases did not display resistance to isoniazid (INH) in settings with relatively low MDR-TB prevalence (one third of all countries and subnational settings). Results indicated the need for INH susceptibility testing in addition to RMP susceptibility testing.

PMID:
22136739
PMCID:
PMC4593497
DOI:
10.5588/ijtld.11.0445
[Indexed for MEDLINE]
Free PMC Article

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