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Int J Immunogenet. 2012 Apr;39(2):106-9. doi: 10.1111/j.1744-313X.2011.01060.x. Epub 2011 Dec 4.

Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis.

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Department of Anatomy, Veterinary School, University of Bristol, Bristol, UK.


We examined single-nucleotide polymorphisms (SNPs) in IL18 and IL18/R1 genes and knee OA. IL18 rs1946518 wild-type allele was more frequently observed in cases (P = 0.04). Haplotype 1 was more frequently observed in cases (P = 0.04). Genetic variation in the promoter region of IL18, but not IL18R1, may be associated with OA.

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