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Open Dent J. 2011;5:163-7. doi: 10.2174/1874210601105010163. Epub 2011 Oct 21.

Closure of an open wound associated with bisphosphonate-related osteonecrosis of the jaw in a breast cancer patient.

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  • 1Department of Communication, College of Arts and Humanities, University of Maryland, College Park, MD, USA.



Many clinicians will not treat patients presenting with bisphosphonate-related osteonecrosis of the jaw following long-term use of bisphosphonates because of the lack of predictable outcomes. MATERICAL AND METHODS: The patient presented with pain from a nonhealing lesion in the posterior maxilla following extraction of the maxillary right third molar. The lesion had not responded to any conventional dental treatment. The patient had suffered from breast cancer, and her treatment included several years of therapy with Zometa (zoledronic acid), a bisphosphonate.


The patient stopped taking Zometa and commenced rinsing with phosphate buffer-stabilized 0.1% chlorine dioxide-containing mouthwash. After 5 months, changes in the morphology of the lesion were noted and the soft tissue had closed over the open wound.


Cessation of bisphosphonate therapy and usage of a phosphate buffer-stabilized 0.1% chlorine dioxide-containing mouthwash lessened the patient's pain and resulted in closure of the soft tissue lesion.


Bisphosphonate; Breast cancer; Cancer.; Osteonecrosis of the Jaw; Zometa

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