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Bioinformatics. 2012 Feb 1;28(3):439-40. doi: 10.1093/bioinformatics/btr664. Epub 2011 Nov 30.

DMAN: a Java tool for analysis of multi-well differential scanning fluorimetry experiments.

Author information

1
Structural Chemistry Program, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland 4111, Australia. conan.wang@griffith.edu.au

Abstract

SUMMARY:

Differential scanning fluorimetry (DSF) is a rapid technique that can be used in structural biology to study protein-ligand interactions. We have developed DMAN, a novel tool to analyse multi-well plate data obtained in DSF experiments. DMAN is easy to install and provides a user-friendly interface. Multi-well plate layouts can be designed by the user and experimental data can be annotated and analysed by DMAN according to the specified plate layout. Statistical tests for significance are performed automatically, and graphical tools are also provided to assist in data analysis. The modular concept of this software will allow easy development of other multi-well plate analysis applications in the future.

AVAILABILITY AND IMPLEMENTATION:

DMAN is implemented in Java to provide a cross-platform compatibility. It is freely available to academic users at http://www.structuralchemistry.org/pcsb/. To download DMAN, users will be asked for their name, institution and email address. A manual can also be downloaded from this site.

CONTACT:

conan.wang@griffith.edu.au; a.hofmann@griffith.edu.au.

PMID:
22135419
DOI:
10.1093/bioinformatics/btr664
[Indexed for MEDLINE]

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