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J Acquir Immune Defic Syndr. 1990;3(11):1023-40.

Immunologic and pathologic manifestations of the infection of rhesus monkeys with simian immunodeficiency virus of macaques.

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Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772.


The striking similarities between simian immunodeficiency virus (SIV)-induced disease in macaque monkeys and HIV-induced disease in humans make the SIV-induced macaque monkey an extraordinarily important model for the study of AIDS. The most significant difference between these lentivirus-induced syndromes is the more rapid progression of disease in SIV-infected monkeys. The immunologic and pathologic manifestations of SIV infections in rhesus monkeys are described.

[Indexed for MEDLINE]

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