Format

Send to

Choose Destination
EMBO Rep. 2011 Dec 23;13(1):83-9. doi: 10.1038/embor.2011.223.

Oxidative stress in the haematopoietic niche regulates the cellular immune response in Drosophila.

Author information

1
Department of Molecular, Cell and Developmental Biology, Molecular Biology Institute, Los Angeles, 610 Charles Young Drive East, Terasaki Life Science Building, Los Angeles, California 90095, USA. sinenko@mail.com

Abstract

Oxidative stress induced by high levels of reactive oxygen species (ROS) is associated with the development of different pathological conditions, including cancers and autoimmune diseases. We analysed whether oxidatively challenged tissue can have systemic effects on the development of cellular immune responses using Drosophila as a model system. Indeed, the haematopoietic niche that normally maintains blood progenitors can sense oxidative stress and regulate the cellular immune response. Pathogen infection induces ROS in the niche cells, resulting in the secretion of an epidermal growth factor-like cytokine signal that leads to the differentiation of specialized cells involved in innate immune responses.

PMID:
22134547
PMCID:
PMC3246251
DOI:
10.1038/embor.2011.223
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center