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Nat Rev Immunol. 2011 Dec 2;12(1):61-6. doi: 10.1038/nri3129.

Experimental mouse tumour models: what can be learnt about human cancer immunology?

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Department of Medical Oncology and the Cancer Vaccine Center, Dana-Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.


The recent demonstration that cancer immunotherapy extends patient survival has reinvigorated interest in elucidating the role of immunity in tumour pathogenesis. Experimental mouse tumour models have provided key mechanistic insights into host antitumour immune responses, and these have guided the development of novel treatment strategies. To accelerate the translation of these findings into clinical benefits, investigators need to gain a better understanding of the strengths and limitations of mouse model systems as tools for deciphering human antitumour immune responses.

[Indexed for MEDLINE]

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