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J Clin Invest. 2011 Dec;121(12):4584-92. doi: 10.1172/JCI57173. Epub 2011 Dec 1.

Syphilis: using modern approaches to understand an old disease.

Author information

1
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA.

Abstract

Syphilis is a fascinating and perplexing infection, with protean clinical manifestations and both diagnostic and management ambiguities. Treponema pallidum subsp. pallidum, the agent of syphilis, is challenging to study in part because it cannot be cultured or genetically manipulated. Here, we review recent progress in the application of modern molecular techniques to understanding the biological basis of this multistage disease and to the development of new tools for diagnosis, for predicting efficacy of treatment with alternative antibiotics, and for studying the transmission of infection through population networks.

PMID:
22133883
PMCID:
PMC3225993
DOI:
10.1172/JCI57173
[Indexed for MEDLINE]
Free PMC Article

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