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Evolution. 2011 Dec;65(12):3625-32. doi: 10.1111/j.1558-5646.2011.01408.x. Epub 2011 Aug 11.

Negative epistasis between α+ thalassaemia and sickle cell trait can explain interpopulation variation in South Asia.

Author information

1
Department of Zoology, University of Oxford, South Parks Road Oxford, OX1 3PS, United Kingdom. bridget.penman@zoo.ox.ac.uk

Abstract

Recent studies in Kenya and Ghana have shown that individuals who inherit two malaria-protective genetic disorders of haemoglobin-α(+) thalassaemia and sickle cell trait-experience a much lower level of malaria protection than those who inherit sickle cell trait alone. We have previously demonstrated that this can limit the frequency of α(+) thalassaemia in a population in which sickle cell is present, which may account for the frequency of α(+) thalassaemia in sub-Saharan Africa not exceeding 50%. Here we consider the relationship between α(+) thalassaemia and sickle cell in South Asian populations, and show that very high levels of α(+) thalassaemia combined with varying levels of malaria selection can explain why sickle cell has penetrated certain South Asian populations but not others.

PMID:
22133230
PMCID:
PMC3263337
DOI:
10.1111/j.1558-5646.2011.01408.x
[Indexed for MEDLINE]
Free PMC Article

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