An obesity-related FTO variant and the risk of preeclampsia in a Finnish study population

J Pregnancy. 2011:2011:251470. doi: 10.1155/2011/251470. Epub 2011 Nov 3.

Abstract

Previous studies have demonstrated a common variant of the obesity and fat mass-related FTO gene, rs9939609, to be associated with obesity, type 2 diabetes, and elevated blood pressure. We investigated whether the FTO SNP rs9939609 is associated with the risk of preeclampsia (PE) in a Finnish study population. 485 women with prior PE and 449 women who had given birth after a normotensive pregnancy were genotyped (TaqMan) for the SNP rs9939609. The prevalences of genotypes AA, AT, and TT were 15%, 53%, and 32%, respectively, among the PE cases, and 16%, 47%, and 37%, respectively, among the controls (P = 0.199). We found no evidence of an association between the FTO SNP rs9939609 and PE. However, our cases were dominated by severe, early-onset PE. Thus, we are unable to exclude an association with the milder, later-onset form of the disease in which the role of maternal metabolic predisposition could be more significant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • Analysis of Variance
  • Body Mass Index
  • Case-Control Studies
  • Chi-Square Distribution
  • Female
  • Finland
  • Genotype
  • Humans
  • Obesity / complications
  • Obesity / genetics
  • Polymorphism, Single Nucleotide*
  • Pre-Eclampsia / genetics*
  • Pregnancy
  • Proteins / genetics*
  • Risk Factors
  • Statistics, Nonparametric
  • Young Adult

Substances

  • Proteins
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO
  • FTO protein, human