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Syst Synth Biol. 2010 Dec;4(4):247-56. doi: 10.1007/s11693-011-9068-5. Epub 2011 Mar 1.

Creating novel protein scripts beyond natural alphabets.


Natural proteins are concatenated amino acids with definite handedness or chirality, with their spatial orientation being preferentially left handed or L-chiral. This paper discusses the biophysics of stereo-chemical perturbation to proteins using D-(α) amino acid and its utility as an additional design alphabet while scripting novel protein structures.


Heterochiral proteins; Polypeptide stereochemistry; Protein design; Protein structure energetics

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