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Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Mar-Apr;4(2):139-52. doi: 10.1002/wnan.170. Epub 2011 Nov 30.

Beyond DNA origami: the unfolding prospects of nucleic acid nanotechnology.

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1
Department of Physics, University of Michigan, Ann Arbor, MI, USA.

Abstract

Nucleic acid nanotechnology exploits the programmable molecular recognition properties of natural and synthetic nucleic acids to assemble structures with nanometer-scale precision. In 2006, DNA origami transformed the field by providing a versatile platform for self-assembly of arbitrary shapes from one long DNA strand held in place by hundreds of short, site-specific (spatially addressable) DNA 'staples'. This revolutionary approach has led to the creation of a multitude of two-dimensional and three-dimensional scaffolds that form the basis for functional nanodevices. Not limited to nucleic acids, these nanodevices can incorporate other structural and functional materials, such as proteins and nanoparticles, making them broadly useful for current and future applications in emerging fields such as nanomedicine, nanoelectronics, and alternative energy.

PMID:
22131292
PMCID:
PMC3360889
DOI:
10.1002/wnan.170
[Indexed for MEDLINE]
Free PMC Article
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